Barrie Police have charged 10 people with drug-related offences following Friday's raid at several residences on Little Avenue and one on Megan Court.
Three other people were arrested on outstanding warrants and six others were released.
Police seized cocaine, crack cocaine, heroin, fentanyl and crystal meth, as well as money.
The street value of the drugs is over $64-hundred.
Three tasers were also seized.
Police began their investigation last month after complaints from people in the neighbourhood about drug trafficking.
Those facing drug charges are from Barrie and the GTA.